Cytiva HiTrap™ Columns, Capto™ PlasmidSelect

Capto™ PlasmidSelect is a chromatography resin that allows supercoiled covalently closed circular forms of plasmid DNA to be separated from open circular forms. The columns are packed with Capto™ PlasmidSelect for purification of supercoiled DNA to high quality for gene therapy and DNA vaccine applications. Capto™ PlasmidSelect is based on a rigid base matrix, delivering excellent pressure-flow properties to plasmid production.

• High-flow purification of supercoiled DNA from research scale to cGMP production.
• Flexible process design due to a large operational window of flow velocities and bed heights.
• Higher throughput for improved productivity and process economy.
• Hydrophilic properties of base matrix prevent non-specific binding.
• BioProcess resin supported for industrial applications.
• Convenient small-scale purification, process development, and scale-up using prepacked HiTrap columns.
• Capto™ PlasmidSelect is based on a rigid base matrix, delivering excellent pressure-flow properties to plasmid production.